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Gene Smith's avatar

The article that you link shows a researcher supporting single digit percentage heritability doesn't actually show what you claim it shows. The article says that a polygenic score for patients with neuroimaging data (with only 27k samples) explained 7.6% of the variance in g.

PGS variance explained != heritability! That's like reporting benchmark results for your machine learning model before its finished training.

The low IQ heritability estimates you do find in the literature such as https://pmc.ncbi.nlm.nih.gov/articles/PMC6411041/ all seem to have the same issue: they estimate SNP heritability based on UK Biobank's fluid intelligence test, but they fail to account for the fact that the test sucks! Gold standard IQ tests have a test-retest correlation of >0.9. UK Biobank's is short, so the test-retest correlation is 0.61. This is massively deflating estimates of SNP heritability, and thus broad sense heritability!

They calculate SNP heritability of 0.19-0.22 when actual SNP heritability (after adjusting for the crappy test) is about 0.3.

But that's just SNP heritability. A good portion of the variance in IQ comes from rare variants (population frequency <1%), and about 20% of it comes from non-linear effects that are going to be very hard to capture without much larger sample sizes.

I have yet to find a credible IQ heritability estimate that's lower than 0.5

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Britni Brown O’Donnell's avatar

The biggest thing I took away from my Instrument Development class in grad school was that an instument is only valid when used for it's intended purpose. The IQ test was originally created to classify French orphans with cognitive delays into categories that could be used to group their educational needs by the program supporting them. Taking IQ measurements outside of this context automatically makes them invalid; the context has changed and the instrument for deciding what an individual's IQ is is no longer applicable. Sure, we can acknowledge that defferent instruments have been designed and used over the years to try to quantify intelligence - we certainly aren't using the same test the French orphans were given- but we've completely shifted the purpose of IQ from grouping students with similar abilities to recieve education suited to them, to making IQ a predictive measure of mental ability and success! And how can a body of research be considered solid on such a shifting foundation?

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