Thank you for pointing out that M1 and M4 agonism is what distinguishes clozapine from other antipsychotics! If one reads the literature closely it is mentioned there from time to time. This has been my pet theory as well. What is concerning, why the negative symptoms decrease is so little as compared with clozapine? Is it a matter of short 5-week trial? or do we need both D2, D3 inhibition and M1 M4 agonism that is polypharmacy with xanomeline/classic antipsychotic?
i don't treat schizophrenia but i treat a lot of bipolar, including bipolar with psychotic features. i'll be interested to learn if this stuff works as an antimanic, and whether it has an anti-depressant kick.
Thank you for pointing out that M1 and M4 agonism is what distinguishes clozapine from other antipsychotics! If one reads the literature closely it is mentioned there from time to time. This has been my pet theory as well. What is concerning, why the negative symptoms decrease is so little as compared with clozapine? Is it a matter of short 5-week trial? or do we need both D2, D3 inhibition and M1 M4 agonism that is polypharmacy with xanomeline/classic antipsychotic?
i don't treat schizophrenia but i treat a lot of bipolar, including bipolar with psychotic features. i'll be interested to learn if this stuff works as an antimanic, and whether it has an anti-depressant kick.